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Some packages pay attention to --enable-feature options to configure, where feature indicates an optional part of the package. They may also pay attention to --with-package options, where package is something like `gnu-as' or `x' (for the X Window System). The README should mention any --enable- and --with- options that the package recognizes.
For packages that use the X Window System, configure can usually find the X include and library files automatically, but if it doesn't, you can use the configure options --x-includes=dir and --x-libraries=dir to specify their locations.